Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
Irène Villa, Chiara Villa, Roberta Crapanzano, Valeria Secchi, M Tawfilas, Elena Trombetta, Laura Porretti, A. Brambilla, Marcello Campione, Yvan Torrente, A. Vedda, Angelo Monguzzi
Abstract
, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
Topics & Concepts
Photodynamic therapyMaterials scienceSinglet oxygenPhotosensitizerNanomaterialsRadiosensitizerCytotoxicityIonizing radiationIrradiationRadiation therapyNanotechnologyPhotochemistryOxygenIn vitroChemistryMedicineOrganic chemistrySurgeryBiochemistryNuclear physicsPhysicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesRadiation Therapy and Dosimetry