Metabolomic profiling, biological evaluation of <i>Aspergillus awamori</i>, the river Nile-derived fungus using epigenetic and OSMAC approaches
Momen M. Lotfy, Ahmed M. Sayed, Asmaa M. AboulMagd, Hossam M. Hassan, Dalia El Amir, Sameh AbouZid, Ahmed O. El‐Gendy, Mostafa E. Rateb, Usama Ramadan Abdelmohsen, Hani A. Alhadrami, Rabab Mohammed
Abstract
, whereas using rice, malt dextrose or nicotinamide can induce groups of cytotoxic metabolites. OPLS-DA results assisted in the putative identification of the induced metabolites that could be responsible for these observed inhibitory activities. This study highlighted how powerful the OSMAC approach in maximizing of the chemical diversity of a single organism. Furthermore, it revealed the power of metabolomics in tracing, profiling and categorizing such chemical diversity and even targeting the possible bioactive candidates which require further scaling up studies in the future.