RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia
William Marion, Tiago Koppe, Chun-Chin Chen, Dahai Wang, Katie Frenis, Sara Fierstein, Prerana Sensharma, Olivia Aumais, Michael Peters, Sonya Ruiz-Torres, Tafadzwa Chihanga, Steffen Boettcher, Akiko Shimamura, Daniel E. Bauer, Thorsten M. Schlaeger, Susanne I. Wells, Benjamin L. Ebert, Daniel T. Starczynowski, Edroaldo Lummertz da Rocha, R. Grant Rowe
Topics & Concepts
BiologyFanconi anemiaRUNX1Progenitor cellCancer researchHaematopoiesisStem cellInduced pluripotent stem cellBone marrow failureMyeloidImmunologyGeneticsCell biologyDNA repairEmbryonic stem cellGeneAcute Myeloid Leukemia ResearchCRISPR and Genetic EngineeringDNA Repair Mechanisms