Directed evolution of cyclic peptides for inhibition of autophagy
Joshua P. Gray, Md Nasir Uddin, Rajan Chaudhari, Margie N. Sutton, Hailing Yang, Philip Rask, Hannah Locke, Brian J. Engel, Nefeli Batistatou, Jing Wang, Brian J. Grindel, Pratip K. Bhattacharya, Seth T. Gammon, Shuxing Zhang, David Piwnica‐Worms, Joshua A. Kritzer, Zhen Lü, Robert C. Bast, Steven W. Millward
Abstract
SUPR peptide mRNA display was used to evolve a cell-permeable, macrocyclic peptide for autophagy inhibition.
Topics & Concepts
AutophagyCyclic peptideChemistryComputational biologyCell biologyBiologyBiochemistryPeptideApoptosisAutophagy in Disease and TherapyClick Chemistry and ApplicationsCarbohydrate Chemistry and Synthesis