Enhanced photodynamic therapy through supramolecular photosensitizers with an adamantyl-functionalized porphyrin and a cyclodextrin dimer
Lei Xia, Jian Wu, Baoxuan Huang, Yun Gao, Jia Tian, Weian Zhang
Abstract
A supramolecular photosensitizer was constructed using a tetra-adamantane-functionalized porphyrin and a dimer of permethyl-β-cyclodextrin through host-guest interaction and self-assembly. The porphyrin/cyclodextrin alternating structure of supramolecular photosensitizers not only enhances the water solubility of the photosensitizers, but also effectively inhibits the aggregation-induced quenching of porphyrin photosensitizers.
Topics & Concepts
PorphyrinPhotodynamic therapyCyclodextrinSupramolecular chemistryDimerChemistryAdamantaneCombinatorial chemistryPhotochemistryOrganic chemistryMoleculeNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies