<i>ppe51</i> Variants Enable Growth of Mycobacterium tuberculosis at Acidic pH by Selectively Promoting Glycerol Uptake
Shelby J. Dechow, Jacob J. Baker, Megan Murto, Robert B. Abramovitch
Abstract
It is puzzling why Mycobacterium tuberculosis (Mtb) cannot grow on glycerol at acidic pH, as it has a carbon source and oxygen, everything it needs to grow. In this study, we found that Mtb limits uptake of glycerol at acidic pH to restrict its growth and that mutations in ppe51 promote uptake of glycerol at acidic pH and enable growth.
Topics & Concepts
GlycerolBiologyMutantBiochemistryGlycerol kinaseWild typeGeneTuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis