The identification of key metabolites and mechanisms during isoniazid/rifampicin-induced neurotoxicity and hepatotoxicity in a mouse model by HPLC-TOF/MS-based untargeted urine metabolomics
Yanqing Song, Jie Ma, Huan Gao, Jinghui Zhai, Yueming Zhang, Jiawei Gong, Xiaoyu Qu, Tingting Hu
Topics & Concepts
ChemistryNeurotoxicityPharmacologyRifampicinIsoniazidUrineToxicityMetabolismMetaboliteMetabolomicsBiochemistryChromatographyAntibioticsMedicinePathologyTuberculosisOrganic chemistryMetabolomics and Mass Spectrometry StudiesPharmacogenetics and Drug MetabolismTryptophan and brain disorders