Remodeling of the Homer-Shank interactome mediates homeostatic plasticity
Whitney E. Heavner, Jonathan D. Lautz, Haley E. Speed, Edward P. Gniffke, Karen B. Immendorf, John P. Welsh, Nathan A. Baertsch, Stephen Smith
Abstract
did not undergo normal PIN rearrangements, suggesting that the proteins encoded by these autism spectrum disorder-linked genes serve as structural hubs for synaptic homeostasis. Our approach demonstrates how changes in the protein content of synapses during homeostatic plasticity translate into functional PIN alterations that mediate changes in neuron excitability.
Topics & Concepts
InteractomeHomeostatic plasticityNeuroscienceSynaptic scalingNeuroplasticityHomeostasisSynaptic plasticityBiologyCell biologyMetaplasticityReceptorGeneticsGeneNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchCellular transport and secretion