Gene Amplification of <i>CYP51B</i> : a New Mechanism of Resistance to Azole Compounds in Trichophyton indotineae
Tsuyoshi Yamada, Takashi Yaguchi, Mari Maeda, Mohamed Mahdi Alshahni, Karine Salamin, Emmanuella Guenova, Marc Feuermann, Michel Monod
Abstract
Trichophyton indotineae causes dermatophytosis that is resistant to terbinafine and azole compounds. The aim of this study was to determine the mechanisms of resistance to itraconazole (ITC) and voriconazole (VRC) in strains of T. indotineae .
Topics & Concepts
AzoleTrichophyton rubrumItraconazoleBiologyMicrobiologyTerbinafineGeneDrug resistanceMultiple drug resistanceVoriconazoleStrain (injury)GeneticsAntifungalAnatomyNail Diseases and TreatmentsPlant Pathogens and Fungal DiseasesAntifungal resistance and susceptibility