Site-selective carbonylation of arenes <i>via</i> C(sp <sup>2</sup> )–H thianthrenation: direct access to 1,2-diarylethanones
Jiajun Zhang, Le‐Cheng Wang, Zhipeng Bao, Xiao‐Feng Wu
Abstract
)-H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modification of complex molecules, which was previously challenging with similar carbonylative Negishi-type reactions.
Topics & Concepts
CarbonylationChemistryMedicinal chemistryStereochemistryCatalysisOrganic chemistryCarbon monoxideCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions