Electrochemical enantioselective dihydroxylation reaction of <i>N</i>-alkenyl nucleobases for the construction of chiral acyclic nucleosides
Qi-Ying Zhang, Pei-Xian Lu, Songlin Wang, Luxin Li, Gui‐Rong Qu, Hai‐Ming Guo
Abstract
A simple and sustainable KI-mediated electrochemical enantioselective dihydroxylation reaction for the synthesis of chiral acyclic nucleosides was developed for the first time with only a 0.1 mol% Os catalyst.
Topics & Concepts
Enantioselective synthesisChemistryDihydroxylationNucleobaseCatalysisElectrochemistryOrganic chemistryCombinatorial chemistryStereochemistryDNABiochemistryElectrodePhysical chemistryElectrocatalysts for Energy ConversionCO2 Reduction Techniques and CatalystsRadical Photochemical Reactions