Ampakine pretreatment enables a single hypoxic episode to produce phrenic motor facilitation with no added benefit of additional episodes
Prajwal P. Thakre, Michael D. Sunshine, David D. Fuller
Abstract
Pretreatment with ampakine CX717 created conditions that enabled an acute bout of moderate hypoxia to evoke phrenic motor facilitation, but this response was not observed when ampakine pretreatment was followed by intermittent hypoxia. Thus, in anesthetized and spinal intact rats, the combination of ampakine and one bout of hypoxia appears ideal for triggering respiratory neuroplasticity.
Topics & Concepts
FacilitationHypoxia (environmental)Phrenic nerveNeuroplasticityAnesthesiaMedicineRespiratory systemNeurosciencePsychologyInternal medicineChemistryOxygenOrganic chemistryNeuroscience of respiration and sleepNeonatal Respiratory Health ResearchNeuroendocrine regulation and behavior