Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
Tsuyoshi Inoshita, Junyi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba‐Fukushima, Nobutaka Hattori, Yuzuru Imai
Abstract
. Moreover, the inactivation of a small GTPase Rab3 and altered Auxilin activity phenocopied Arl8 accumulation. The accumulation of Arl8-positive vesicles is UNC-104-dependent and modulated by PD-associated genes, Auxilin, VPS35, RME-8, and INPP5F, indicating that VPS35, RME-8, and INPP5F are upstream regulators of Lrrk. These results indicate that certain PD-related genes, along with LRRK2, drive precise neuroaxonal transport of dense core vesicles.
Topics & Concepts
LRRK2Cell biologyVesicleSynaptic vesicleRabBiologyAxoplasmic transportOrganelleKinaseVesicular transport proteinRegulatorSmall GTPaseGeneGTPaseBiochemistrySignal transductionMutationMembraneCellular transport and secretionParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research