Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy <i>in vivo</i>
Wanfu Men, Peiyao Zhu, Siyuan Dong, Wenke Liu, Kun Zhou, Yu Bai, Xiangli Liu, Shulei Gong, Shuguang Zhang
Abstract
experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.
Topics & Concepts
DoxorubicinIn vivoDrug deliveryLiposomeCytotoxicityMaterials scienceHyaluronic acidA549 cellDrugEx vivoBiophysicsControlled releaseTargeted drug deliveryNanoparticleDrug carrierIn vitroNanotechnologyPharmacologyChemistryChemotherapyBiochemistryMedicineBiologySurgeryBiotechnologyAnatomyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery