Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis
Hongxia Tang, Chaoqun Li, Yue Zhang, Hongyue Zheng, Ying Cheng, Jingjing Zhu, Xiaojie Chen, Zhihong Zhu, Ji‐Gang Piao, Fanzhu Li
Abstract
Such a GSH-starvation therapeutic strategy would cause multi-path programmed cell death and could be a promising strategy for cancer therapy.
Topics & Concepts
GlutathioneIntracellularOxidative stressHomeostasisChemistryCell biologyRedoxCancer cellAntioxidantBiochemistryCancerBiologyMedicineInternal medicineEnzymeOrganic chemistrySulfur Compounds in BiologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis