Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents
Tamara Zorbaz, David Maliňák, Tereza Hofmanova, Nikola Maraković, Suzana Žunec, Nikolina Maček Hrvat, Rudolf Andrýs, Miroslav Psotka, Antonio Zandona, Jana Svobodová, Lukáš Prchal, Sanja Fingler, Maja Katalinić, Zrinka Kovarik, Kamil Musílek
Topics & Concepts
ChemistryOximeTabunNerve agentSarinAcetylcholinesteraseButyrylcholinesteraseNucleophileHalogenationHalogenStereochemistrySomanOrganic chemistryAchéEnzymeAlkylCatalysisCholinesterase and Neurodegenerative DiseasesPesticide Exposure and ToxicityEnvironmental Toxicology and Ecotoxicology