Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2
Shinako Kakuda, Rachel K. LoPilato, Atsuko Ito, Robert S. Haltiwanger
Abstract
fucosylation on EGF9 was important for trafficking of both NOTCH1 and NOTCH2. Together, these studies provide new insights into the differential regulation of NOTCH1 and NOTCH2 by Notch ligands and Fringe enzymes.
Topics & Concepts
Notch signaling pathwayJAG1HES1FucoseCell biologyBiologyLigand (biochemistry)Cell fate determinationMutantChemistryMolecular biologyBiochemistrySignal transductionReceptorGeneGlycoproteinTranscription factorCerebrovascular and genetic disordersDevelopmental Biology and Gene RegulationCongenital heart defects research