The relationship between telomere length and aging-related diseases
Xuanqi Huang, Leyi Huang, Jiameng Lu, Lijuan Cheng, Du An Wu, Linmeng Li, Shuting Zhang, Xin Lai, Lu Xu
Abstract
The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies on aging and disorders associated with aging. Cellular senescence and aging are known to be caused by telomere shortening. Telomere length (TL) has emerged as a biomarker under intense scrutiny, and its widespread use in investigations of diseases tied to advancing age. This review summarizes the current knowledge of the association between telomeres and aging-related diseases, explores the important contribution of dysfunctional telomeres to the development and progression of these diseases, and aims to provide valuable insights for the development of novel therapeutic strategies.