Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency
Mateusz Stoszko, Abdullah M. S. Al‐Hatmi, Anton Škríba, Michael D. Röling, Enrico Ne, Raquel Crespo, Yvonne M. Mueller, Mohammad Javad Najafzadeh, Joyce B. Kang, Renata Ptáčková, Elizabeth H LeMasters, Pritha Biswas, Alessia Bertoldi, Tsung Wai Kan, Elisa De Crignis, Miroslav Šulc, Joyce H.G. Lebbink, Casper Rokx, Annelies Verbon, Wilfred F. J. van IJcken, Peter D. Katsikis, Robert‐Jan Palstra, Vladimı́r Havlı́ček, Sybren de Hoog, Tokameh Mahmoudi
Abstract
T cells. GTX directly disrupted 7SK snRNP by targeting La-related protein 7 (LARP7), releasing active P-TEFb, which phosphorylated RNA polymerase II (Pol II) C-terminal domain (CTD), inducing HIV transcription.
Topics & Concepts
snRNPP-TEFbGliotoxinBiologyChemistryBiochemistryRNAMicrobiologyRibonucleoproteinAspergillus fumigatusGene expressionGenePromoterHIV Research and TreatmentMicrobial Natural Products and Biosynthesisvaccines and immunoinformatics approaches