Directed evolution of <i>Escherichia coli</i> surface-displayed <i>Vitreoscilla</i> hemoglobin as an artificial metalloenzyme for the synthesis of 5-imino-1,2,4-thiadiazoles
Yaning Xu, Fengxi Li, Hanqing Xie, Yuyang Liu, Weiwei Han, Junhao Wu, Lei Cheng, Chunyu Wang, Zhengqiang Li, Lei Wang
Abstract
Escherichia coli surface-displayed Vitreoscilla hemoglobin as an artificial metalloenzyme for the synthesis of 5-imino-1,2,4-thiadiazoles.
Topics & Concepts
ThiadiazolesEscherichia coliHemoglobinChemistryBiochemistryDirected evolutionBiologyMedicinal chemistryGeneMutantClick Chemistry and ApplicationsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions