The dynamic nuclear envelope: resilience in health and dysfunction in disease
Ayse M. Turkmen, Natasha O. Saik, Katharine S. Ullman
Abstract
The canonical appearance of the nucleus depends on constant adaptation and remodeling of the nuclear envelope in response to changing biomechanical forces and metabolic demands. Dynamic events at the nuclear envelope play a vital role in supporting key nuclear functions as well as conferring plasticity to this organelle. Moreover, imbalance of these dynamic processes is emerging as a central feature of disease etiology. This review focuses on recent advances that shed light on the myriad events at the nuclear envelope that contribute to resilience and flexibility in nuclear architecture.
Topics & Concepts
Envelope (radar)BiologyFlexibility (engineering)Resilience (materials science)Adaptation (eye)Psychological resilienceNucleusComputational biologyNeuroscienceComputer sciencePhysicsPsychologyPsychotherapistRadarMathematicsStatisticsTelecommunicationsThermodynamicsNuclear Structure and FunctionRNA Research and SplicingRNA regulation and disease