Host–Guest Interaction-Based Supramolecular Self-Assemblies for H<sub>2</sub>O<sub>2</sub> Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy
Caiping Liu, Huaitian Bu, Xiao Duan, Hui Li, Yang Bai
Abstract
Given that light is hard to reach deep tumor tissue, how to enhance photodynamic therapy (PDT) efficacy is a big challenge. Herein, we proposed the supramolecular polymer self-assemblies (HACP) with bis[2,4,5-trichloro-6 (pentyloxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) to realize the chemiluminescence resonance energy transfer (CRET)-induced generation of 1 O 2 in situ. HACP was prepared by cinnamaldehyde-modified hyaluronic acid (HA-CA) and β-cyclodextrin-modified protoporphyrin IX (β-CD-PPIX) via host–guest interactions. The CA moiety could elevate H 2 O 2 levels for the enhanced production of chemical energy and macrocyclic CD could enhance the stacking distance of PPIX for enhanced 1 O 2 yield. Thus, HACP@CPPO exhibited excellent antitumor performance without light irradiation.