The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, Koichiro Sueyoshi, Dilan Aytan, Yong Shen, Wolfgang G. Junger
Abstract
influx, and pseudopod protrusion at the front. This regulatory function of P2Y11 receptors depended on their subcellular redistribution and autocrine stimulation by cellular ATP release and was perturbed by indiscriminate global stimulation. We conclude that excessive extracellular ATP-such as in response to inflammation, sepsis, and cancer-disrupts this autocrine feedback mechanism, which results in defective T cell migration, impaired T cell function, and loss of host immune defense.
Topics & Concepts
Purinergic receptorAutocrine signallingCell biologyReceptorBiologyPurinergic signallingMitochondrionExtracellularStimulationChemotaxisEndocrinologyBiochemistryAdenosine receptorAgonistAdenosine and Purinergic SignalingImmune Cell Function and InteractionMacrophage Migration Inhibitory Factor