Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production
Weijian Zhang, Hao Xiong, Jiaqi Pang, Zhongwu Su, Lan Lai, Hanqing Lin, Bingquan Jian, Wuhui He, Haidi Yang, Yiqing Zheng
Topics & Concepts
OtotoxicityReactive oxygen speciesOxidative stressCisplatinApoptosisMitochondrionChemistryCell biologyMitochondrial ROSTranscription factorActivator (genetics)Hair cellPharmacologyBiologyBiochemistryCochleaAnatomyGeneGeneticsChemotherapyGenomics, phytochemicals, and oxidative stressMicroRNA in disease regulationHearing, Cochlea, Tinnitus, Genetics