Intrinsic role of chaperone-mediated autophagy in cancer stem cell maintenance
Jaione Auzmendi-Iriarte, Ander Matheu
Abstract
compared to healthy tissue, with this expression being positively associated with malignancy grade, TMZ resistance and lower patient survival. These results reveal a novel function of CMA as an intrinsic regulator of GSC tumorigenic properties and highlight its relevance in GBM progression.
Topics & Concepts
BiologyAutophagyDownregulation and upregulationStem cellCancer researchCell biologyCancer stem cellBAG3GliomaApoptosisGeneticsGeneAutophagy in Disease and TherapyMicroRNA in disease regulationRNA modifications and cancer