Gene therapy has been shown to be valuable for understanding complex disease pathophysiologies

Abstract

The CRISPR/Cas9 framework has been shown to be an important tool for thestudy of pathophysiological mechanisms of diverse diseases since its discoveryand development. CRISPR/Cas9 is inhibited by biological and technicalobstacles in regards to their presence in post motor arteries, as well as to thepossible side effects on the heart. These are the specific cell types of fibroblasts,the vascular endothelial cells, and the target cells for this treatment are cardiacfibroblasts, which have an endothelial cell structure, and smooth muscle cells.The general medical community would need to invest in advanced services inorder to regularize this approach in the treatment of cardiovascular disease.

Topics & Concepts