Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
Eleonora Cataldi, Martina Raschig, Marcus Gutmann, Patrick T. Geppert, Matthias Ruopp, Marvin Schock, Hubert Gerwe, Rüdiger Bertermann, Lorenz Meinel, Maik Finze, Agnieszka Nowak‐Król, Michael Decker, Tessa Lühmann
Abstract
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site-specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.
Topics & Concepts
AzobenzenePhotoswitchPhotoisomerizationPeptideConjugated systemChemistryAmphiphileStereochemistryBiophysicsIsomerizationPhotochemistryMoleculeOrganic chemistryBiochemistryBiologyCopolymerPolymerCatalysisPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchSupramolecular Self-Assembly in Materials