Porcine Epidemic Diarrhea Virus Infection Disrupts the Nasal Endothelial Barrier To Favor Viral Dissemination
Jianda Li, Yuchen Li, Peng Liu, Xiuyu Wang, Yichao Ma, Qiu Zhong, Qian Yang
Abstract
models, we determined that the released MMP-7 contributed to the destruction of endothelial barrier, and the released proinflammatory cytokines activated ECs to facilitate PBMCs migration. Moreover, the virus further exploited the migrated cells to promote viral dissemination. Thus, our results provide new insights into the mechanisms underlying endothelial dysfunction induced by coronavirus infection.
Topics & Concepts
BiologyVirologyVirusDiarrheaViral infectionViral entryImmunologyViral replicationPathologyMedicineAnimal Virus Infections StudiesVirus-based gene therapy researchViral gastroenteritis research and epidemiology