Design, synthesis and<i>in vitro</i>cytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors
Jay Prakash Soni, Shrilekha Chilvery, Anamika Sharma, G. Nikitha Reddy, Chandraiah Godugu, Nagula Shankaraiah
Abstract
was <1.73 μM). Moreover, molecular modeling studies affirmed the constant accommodation of compound 6c at the active pocket of tubulin, establishing many electrostatic and hydrophobic interactions with the active pocket's residues. The tubulin-6c complex was stable during the MD simulation for 50 ns with the recommended range of RMSD value (2-4 Å) for each pose.
Topics & Concepts
CytotoxicityTubulinChemistryApoptosisIC50StereochemistryIn vitroCell cycleCell cultureBiochemistryBiologyMicrotubuleCell biologyGeneticsSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications