Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole
Jephte Y. Akakpo, Matthew W. Jaeschke, Anup Ramachandran, Steven C. Curry, Barry H. Rumack, Hartmut Jaeschke
Topics & Concepts
AntidoteAcetylcysteineAcetaminophenPharmacologyMitochondrial biogenesisLiver injuryTFAMHepatocyteApoptosisChemistryNRF1MedicineLiver regenerationMitochondrionToxicityInternal medicineBiologyIn vitroBiochemistryRegeneration (biology)Cell biologyAntioxidantDrug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationDrug Transport and Resistance Mechanisms