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Development of novel thiazole-based hybrids as DNA gyrase inhibitors: design, synthesis, in silico and in vitro antibacterial evaluation

Mahesh D. Vaghasiya, Jigarkumar V. Mendapara, Iqrar Ahmad, Harun Patel, Dhanji P. Rajani, Premlata Kumari

2024Journal of the Iranian Chemical Society10 citationsDOI

Topics & Concepts

ThiazoleDNA gyraseLipophilicityIn silicoChemistryDocking (animal)Combinatorial chemistrySubstituentLead compoundEscherichia coliIn vitroStereochemistryProtein Data Bank (RCSB PDB)TrifluoromethylMinimum inhibitory concentrationSmall moleculeAntibacterial activityBiochemistryBiologyOrganic chemistryBacteriaGeneticsGeneNursingMedicineAlkylCancer therapeutics and mechanismsSynthesis and biological activityClick Chemistry and Applications
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