Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen‐printed carbon electrode
Karla Cortés, Juan José Triviño, Veróníca Arancibia
Abstract
Abstract Electrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen–printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L −1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L −1 , respectively. The method was applied in the PAR‐ASA‐CAF determination on pharmaceutical formulations.
Topics & Concepts
ElectrodeCaffeineStripping (fiber)ElectrochemistryVoltammetryChemistryPharmaceutical formulationSquare waveDetection limitNuclear chemistryChromatographyMaterials sciencePhysical chemistryComposite materialPhysicsVoltageQuantum mechanicsEndocrinologyMedicineElectrochemical sensors and biosensorsAnalytical Chemistry and SensorsAdvanced Chemical Sensor Technologies