Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae
Jinghui Zhang, Weijie Ye, Kaifeng Wu, Shengnan Xiao, Yuqiang Zheng, Zhaoche Shu, Yibing Yin, Xuemei Zhang
Abstract
Streptococcus pneumoniae is a major human pathogen, and its virulence factors and especially the capsular polysaccharide have been extensively studied. In addition to virulence components that are present on its cell surface that directly interact with the host, S. pneumoniae undergoes a spontaneous and reversible phase variation that allows survival in different host environments.
Topics & Concepts
Streptococcus pneumoniaeRegulatorMicrobiologyVariation (astronomy)Phase variationBiologyGeneGeneticsVirulenceAntibioticsPhysicsAstrophysicsPneumonia and Respiratory InfectionsStreptococcal Infections and TreatmentsNeonatal and Maternal Infections