PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression
Yang Liu, Dawei Ma, Yuepeng Cao, Dongzheng Li, Xin Zhou, Jifeng Feng, Jun Bao
Abstract
PRMT5 functionally associates with EZH2 to promote CRC progression through epigenetically repressing CDKN2B expression. Thus, our findings raise the possibility that combinational intervention of PRMT5 and EZH2 may be a promising strategy for CRC therapy.
Topics & Concepts
Protein arginine methyltransferase 5EZH2Chromatin immunoprecipitationBiologyMethylationMethyltransferaseCancer researchMolecular biologyHistone methyltransferaseDNA methylationBisulfite sequencingGene expressionPromoterGeneGeneticsCancer-related gene regulationEpigenetics and DNA Methylation