Green synthesis of 3-methyl-4-(hetero)aryl methylene isoxazole-5(4<i>H</i>)-ones using WEOFPA/glycerol: evaluation of anticancer and electrochemical behaviour properties
Krishnappa B. Badiger, Santosh Y. Khatavi, Kantharaju Kamanna
Abstract
anticancer evaluation of the synthesized compounds (4h-4o) against lung cancer cells was performed, and among them, 4j, 4k, 4m, and 4o exhibited excellent anticancer activity and compounds 4i and 4n moderate inhibitory activity against lung cancer A549 cells to the reference drug doxorubicin. Furthermore, the derivatives were subjected to electrochemical behaviour studies using cyclic voltammetry and they showed intensive oxidation and reduction potential and also showed excellent anti-oxidant agents. Based on this research study, more and more novel structures of isoxazoles are being designed and synthesized, and their electrochemical behaviour and anticancer activities are studied for the development of novel drug-like candidates.