Glycine Lipids of Porphyromonas gingivalis Are Agonists for Toll-Like Receptor 2
Frank C. Nichols, Robert B. Clark, Yaling Liu, Anthony A. Provatas, Christopher Dietz, Qiang Zhu, Yu‐Hsiung Wang, Michael B. Smith
Abstract
The serine-glycine dipeptide lipid classes, including lipid 430 and lipid 654, are produced by the periodontal pathogen Porphyromonas gingivalis and can be detected in lipid extracts of diseased periodontal tissues and teeth of humans. Both serine-glycine lipid classes were previously shown to engage human and mouse Toll-like receptor 2 (TLR2) and to inhibit mouse osteoblast differentiation and function through engagement of TLR2. It is not clear if other lipids related to serine-glycine lipids are also produced by P. gingivalis .
Topics & Concepts
Porphyromonas gingivalisTLR2SerineGlycineToll-like receptorLipid AReceptorBiologyPeriodontal pathogenMicrobiologyLipid metabolismBiochemistryTLR4BacteriaInnate immune systemLipopolysaccharideAmino acidImmunologyPhosphorylationGeneticsImmune Response and InflammationAntimicrobial Peptides and ActivitiesOral microbiology and periodontitis research