Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection
Karin Dijkman, Nacho Aguiló, Charelle Boot, Sam Hofman, Claudia C. Sombroek, Richard A. W. Vervenne, Clemens H. M. Kocken, Dessislava Marinova, Jelle Thole, Esteban Rodríguez, Michel Vierboom, Krista G. Haanstra, Eugenia Puentes, Carlos Martı́n, Frank A. W. Verreck
Abstract
infection, local T cells expressed high levels of mucosal homing and tissue residency markers. Our data show that pulmonary MTBVAC administration has the potential to enhance its efficacy and justifies further exploration of mucosal vaccination strategies in preclinical efficacy studies.
Topics & Concepts
VaccinationTuberculosisImmune systemImmunologyVirologyMedicinePathologySARS-CoV-2 and COVID-19 ResearchTuberculosis Research and EpidemiologyImmune responses and vaccinations