Lack of CD8 <sup>+</sup> T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer
Brendan Horton, Duncan M. Morgan, Noor Momin, Maria Zagorulya, Elen Torres-Mejia, Vidit Bhandarkar, K. Dane Wittrup, J. Christopher Love, Stefani Spranger
Abstract
A lung cancer–specific form of CD8 + T cell dysfunction is established during T cell priming and contributes to ICB resistance.
Topics & Concepts
Priming (agriculture)EffectorBlockadeCD8Cytotoxic T cellBiologyCancer researchT cellImmunologyCellCell biologyImmune systemGeneticsReceptorIn vitroGerminationBotanyCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction