Kynurenine‐3‐monooxygenase: A new direction for the treatment in different diseases
Yifei Lü, Mingmei Shao, Tao Wu
Abstract
Kynurenine-3-monooxygenase (KMO) is an enzyme that relies on nicotinamide adenine dinucleotide phosphate (NADP), a key site in the kynurenine pathway (KP), which has great effects on neurological diseases, cancer, and peripheral inflammation. This review mainly pay attention to the research of KMO mechanism for the treatment of different diseases, and hopes to provide assistance for clinical and drug use. KMO controlling the chief division of the KP, which directly controls downstream product quinolinic acid (QUIN) and indirectly controls kynurenic acid (KYNA), plays an important role in many diseases, especially neurological diseases.
Topics & Concepts
KynurenineQuinolinic acidKynurenic acidKynurenine pathwayNicotinamide adenine dinucleotide phosphatePharmacologyChemistryMonooxygenaseDrug targetNicotinamide adenine dinucleotideEnzymeBiochemistryMedicineTryptophanNAD+ kinaseAmino acidCytochrome P450Oxidase testTryptophan and brain disordersStress Responses and CortisolGut microbiota and health