Phen-2NO, a new <i>C</i><sub>2</sub>-symmetric rigid-featured tetradentate ligand, and its application in the asymmetric alkylation reaction of indoles
Zi‐Yue Chen, Ke‐Lan Xu, Xirui Wang, Pan Hu, Wei-Yan Jiang, Yifeng Dai, Li‐Jun Peng, Xiong‐Li Liu
Abstract
A new class of C 2 -symmetric rigid-featured chiral phen ligands that provide the N , N , O , O -tetradentate coordination of the phen moiety and two additional N , N -dioxides were rationally designed and developed.
Topics & Concepts
ChemistryAlkylationLigand (biochemistry)StereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisReceptorBiochemistryAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisAsymmetric Hydrogenation and Catalysis