A natural anthraquinone derivative shikonin synergizes with AZD9291 against wtEGFR NSCLC cells through reactive oxygen species-mediated endoplasmic reticulum stress
Xiu Hu, Zuoyan Zhang, Lin‐wen Wu, Linghui Zeng, Hui Chen, Huajian Zhu, Jiankang Zhang, Jiaan Shao, Chong Zhang, Yang-ling Li, Neng-ming Lin
Topics & Concepts
Reactive oxygen speciesUnfolded protein responseApoptosisT790MCancer researchPropidium iodideChemistryWestern blotPharmacologyMolecular biologyMedicineBiologyBiochemistryProgrammed cell deathMutationKRASGeneBioactive Compounds and Antitumor AgentsCancer, Hypoxia, and MetabolismChemotherapy-induced cardiotoxicity and mitigation