Caffeine can alleviate non-alcoholic fatty liver disease by augmenting LDLR expression <i>via</i> targeting EGFR
Yewei Huang, Litian Wang, Meng Zhang, Yan Nie, Jinbo Yang, Wen-Luer Meng, Xuanjun Wang, Jun Sheng
Abstract
results, we found that caffeine could also activate EGFR-ERK1/2 signaling and promote the LDLR expression in ApoE KO mice. In summary, caffeine can enhance the LDLR expression by directly binding to EGFR and activating the EGFR-ERK1/2 signaling pathway. EGFR signaling may represent a novel target for the prevention and treatment of NAFLD.
Topics & Concepts
Fatty liverCaffeineAlcoholic liver diseasePharmacologyLDL receptorChemistryMedicineDiseaseBiochemistryEndocrinologyInternal medicineCholesterolLipoproteinCirrhosisBerberine and alkaloids researchGinseng Biological Effects and ApplicationsLiver Disease Diagnosis and Treatment