Genomic Screening for Malignant Hyperthermia Susceptibility
Leslie G. Biesecker, Robert T. Dirksen, Thierry Girard, Philip M. Hopkins, Sheila Riazi, Henry Rosenberg, Kathryn M. Stowell, James L. Weber
Abstract
It is timely to consider the utility and practicability of screening for malignant hyperthermia susceptibility using genomic testing. Here the authors pose a simple, but bold question: what would it take to end deaths from malignant hyperthermia? The authors review recent advances and propose a scientific and clinical pathway toward this audacious goal to provoke discussion in the field.
Topics & Concepts
MedicineMalignant hyperthermiaHyperthermiaIntensive care medicineComputational biologyPathologyInternal medicineBiologyCardiac electrophysiology and arrhythmiasIon channel regulation and functionCardiovascular Effects of Exercise