Ru(<scp>ii</scp>)-catalyzed C6-selective C–H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors
Yangjie Fu, Zhaohui Wang, Qiyu Zhang, Zhiyu Li, Hong Liu, BI Xiao-ling, Jiang Wang
Abstract
In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(ii) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy, and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility, and mechanistic studies were conducted. It offers a direct and efficient way to synthesize pyridone derivatives.
Topics & Concepts
CarbeneCatalysisChemistrySelectivityRutheniumCombinatorial chemistryFunctional groupOrganic chemistryPolymerCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions