Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond
Shuichi Sugiyama, Toshiyuki Akiyama, Yoshiyuki Taoda, Tsutomu Iwaki, Eriko Matsuoka, Erika Akihisa, Takahiro Seki, Tomokazu Yoshinaga, Takashi Kawasuji
Topics & Concepts
ChemistryIntramolecular forceHydrogen bondStereochemistryAllosteric regulationIntegraseSubstituentCCR5 receptor antagonistPyridineMoietyIntegrase inhibitorCombinatorial chemistryHuman immunodeficiency virus (HIV)Medicinal chemistryEnzymeBiochemistryMoleculeOrganic chemistryChemokineVirologyReceptorViral loadChemokine receptorAntiretroviral therapyGeneBiologyHIV Research and TreatmentHIV/AIDS drug development and treatmentHepatitis C virus research