Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells
Xin Jin, Liansheng Gong, Ying Peng, Le Li, Gang Liu
Abstract
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Topics & Concepts
Gene knockdownCisplatinHypoxia (environmental)EnhancerCancer researchTranscription factorChemistryTranscription (linguistics)In vivoCell biologyBiologyGeneChemotherapyBiochemistryOxygenGeneticsPhilosophyLinguisticsOrganic chemistryGenomics, phytochemicals, and oxidative stressCancer, Hypoxia, and MetabolismGlutathione Transferases and Polymorphisms