Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Gianluca Destro, Kaisa Horkka, Olivier Loreau, David‐Alexandre Buisson, Lee Kingston, Antonio Del Vecchio, Magnus Schou, Charles S. Elmore, Frédéric Taran, Thibault Cantat, Davide Audisio
Abstract
Abstract A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO 2 , this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activity valuable for distribution studies.
Topics & Concepts
ChemistryAcetic acidIsotopes of carbonTransition metalCarbon fibersCarbon-14IsotopeInorganic chemistryOrganic chemistryCatalysisMaterials scienceTotal organic carbonComposite materialComposite numberPhysicsQuantum mechanicsChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisCoordination Chemistry and Organometallics