Reference genome choice compromises population genetic analyses
Maria Akopyan, Matthew Genchev, Ellie E. Armstrong, Jazlyn A. Mooney
Topics & Concepts
BiologyGenomeEvolutionary biologyPopulationGeneticsReference genomeGenetic variationGenetic diversitySingle-nucleotide polymorphismPopulation genomicsGenomicsNatural selectionNucleotide diversityEffective population sizeAssociation mappingQuantitative trait locusOutlierChromosomeComputational biologyPopulation geneticsApproximate Bayesian computationGenome-wide association studyHuman evolutionary geneticsWhole genome sequencingPopulation sizeGenome evolutionGenetic variabilityGenetic associationAllele frequencyEvolution and Genetic DynamicsCancer Genomics and DiagnosticsGenomics and Rare Diseases