Diastereoselective construction of cage-like and bridged azaheterocycles through dearomative maximization of the reactive sites of azaarenes
Hong-Jie Miao, Xuguan Bai, Lele Wang, Junhui Yu, Zhanwei Bu, Qilin Wang
Abstract
A highly diastereoselective multicomponent dearomative multifunctionalization of <italic>N</italic>-alkyl activated azaarenes with 1,5-diazapentadienium salts has been developed to access structurally rigid and synthetically challenging cage-like and bridged azaheterocycles.
Topics & Concepts
ChemistryCageAlkylCombinatorial chemistryMedicinal chemistryOrganic chemistryCombinatoricsMathematicsCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacology