Co-Catalyzed Direct Regio- and Enantioselective Intermolecular γ-Amination of <i>N</i>-Acylpyrazoles
Xin Fu, Hao Yu, He‐Yuan Bai, Abing Duan, Shu‐Yu Zhang
Abstract
-acylpyrazoles that delivers the corresponding γ-amination products in good regio- and enantioselectivity has been established. Moreover, the nitrogen-containing compounds could be easily synthesized. DFT calculations have been provided to explain regio- and enantioselectivity for this γ-amination. The chiral γ-amination products were readily converted into the chiral γ-amino acid derivatives.
Topics & Concepts
AminationEnantioselective synthesisChemistryCatalysisOrganic chemistryIntermolecular forceCobaltRegioselectivityCombinatorial chemistryMoleculeSynthesis and Catalytic ReactionsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods